Lab of Neuroscience

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2019

▼ 2019

Tanaka, H., Sakaguchi, D., Hirano, T. (2019)
Amyloid-beta oligomers suppress subunit-specific glutamate receptor increase during LTP.
Alzehimer's & Dementia: Translational Research & Clinical Interventions (In press)

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2018

▼ 2018

Inoshita, T., Hirano, T. (2018)
Occurence of long-term depression in the cerebellar flocculus during adaptaion of optokinetic response.
eLife 7, e36209, doi: 10.7554/eLife.36209

Funahashi, J., Tanaka, H., Hirano, T. (2018)
Visualization of synchrnous or asyunchrnous release of single synaptic vesicle in active-zone-like membrane formed on neuroligin-coated glass surface.
Frontiers in Cellular Neuroscience 12, 140, doi: 10.3389/fncel.2018.00140

Fujii, S., Tanaka, H., Hirano, T. (2018)
Suppression of AMPA receptor exocytosis contributes to hippocampal LTD.
Journal of Neuroscience, 38, 5523-5537. doi: 10.1523/JNEUROSCI.3210-17.2018

Merkurjev, D., Hong, WT., Iida, K., Oomoto, I., Goldie, BJ., Yamaguti, H., Ohara, T., Kawaguchi, SY., Hirano, T., Martin, KC., Pellegrini, M., Wang, DO. (2018)
Synaptic m6A epitranscriptome reveals functional partitioning of localized transcripts for dynamic tripartite synapse modulation.
Nature Neuroscience, 21, 1004-1014.

Sumitomo A, Yukitake H, Hirai K, Horike K, Ueta K, Chung Y, Warabi E, Yanagawa T, Kitaoka S, Furuyashiki T, Narumiya S, Hirano T, Niwa M, Sibille E, Hikida T, Sakurai T, Ishizuka K, Sawa A, Tomoda T. (2018)
Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABA(A) receptor trafficking in pyramidal neurons.
Hum. Mol. Genet. (In Press) doi: 10.1093/hmg/ddy219.

Hirano, T. (2018)
Regulation and interaction of multiple types of synaptic plasticity in a Purkinje neuron and their contribution to motor learning.
Cerebellum, 17, 756-765. doi: 10.1007/s12311-018-0963-0

Hirano, T. (2018)
Purkinje neurons: development, morphology and function.
Cerebellum, 17, 699-700. doi: 10.1007/s12311-018-0985-7

Hirano, T. (2018)
Visualization of exo- and endocytosis of AMPA receptors during hippocampal synaptic plasticity around postsynaptic-like membrane formed on glass surface.
Frontiers in Cellular Neuroscience, 12, 442, doi: 10.3389/fncel.2018.00442

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2017

▼ 2017

Fujii, S., Tanaka, H. & Hirano, T. (2017)
Detection and characterization of individual endocytosis of AMPA-type glutamate receptor around postsynaptic membrane.
Genes to Cells 22, 583-590.

Wakita, R., Tanabe, S., Tabei, K., Funaki, A., Inoshita, T. & Hirano, T. (2017)
Differential regulations of vestibulo-ocular reflex and optokinetic response by beta- and alpha2-adrenergic receptors in the cerebellar flocculus.
Scientific Reports 7, 3944, doi: 10.1038/s41598-017-04273-9.

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2016

▼ 2016

Bando, Y., Irie, K.,Shimomura, T., Umeshima, H.,Kushida, Y.,Kengaku, M.,Fujiyoshi, Y., Hirano, T.& Tagawa Y. (2016)
Control of spontaneous Ca2+ transients is critical for neuronal maturation in the developing neocortex.
Cerebral Cortex 26, 106-117

Nakamura, Y. & Hirano, T. (2016)
Intracellular Ca2+ thresholds for induction of excitatory long-term depression and inhibitory long-term potentiation in a cerebellar Purkinje neuron.
Biochem. Biophys. Res. Commun 469, 803-808.

Hirano, T., Yamazaki, Y. & Nakamura, Y. (2016)
LTD, RP and motor learning.
Cerebellum 15, 51-53.

Hirano, T. (2016)
GABA pathways and receptors.
In "Essentials of cerebellum and cerebellar disorders", Springer

＋

2015

▼ 2015

Hagihara, K. M., Murakami, T., Yoshida, T., Tagawa, Y. & Ohki, K. (2015)
Neuronal activity is not required for the initial formation and maturation of visual selectivity.
Nature Neurosci. 12, 1780-1788.

＋

2014

▼ 2014

Tanaka, H., Fujii, S. & Hirano, T. (2014)
Live-cell imaging of receptors around postsynaptic membrane formed on adhesion-protein-coated glass.
Nature Protocols 9, 76-89.

Nagasaki, N., Hirano, T. & Kawaguchi, S. (2014)
Opposite regulation of sustained CaMKII activity by alpha and beta subunits impacts inhibitory synaptic plasticity.
J. Physiol. 592, 4891-4909.

Bando Y, Hirano T & Tagawa Y. (2014)
Dysfunction of KCNK potassium channels impairs neuronal migration in the developing mouse cerebral cortex.
Cerebral Cortex, 24, 1017-1029

Hirano, T. & Kawaguchi, S. (2014)
Regulation and functional roles of rebound potentiation at cerebellar stellate cell - Purkinje cell synapse.
Frontiers in Cellular Neuroscience 8, 42: 1-8. doi: 10.3389/fncel.2014.00042

Hirano, T. (2014)
Around LTD hypothesis in motor learning.
Cerebellum 12, 645-650. DOI:10.1007/s12311-014-0581-4

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2013

2013

Kawaguchi S & Hirano T. (2013)
Gating of long-term depression by CaMKII through enhanced cGMP signaling in cerebellar Purkinje cells.
J.Physiol 591,1707-1730.

Hirano T. (2013)
Long-term depression and other synaptic plasticity in the cerebellum.
Proceedings of the Japan Academy,Series B 89:183-195.

Yamashita M, Kawaguchi S & Hirano T. (2013)
Contribution of postsynaptic GluD2 to presynaptic R-type Ca2+ channel function, glutamate release and long-term potentiation at parallel fiber to Purkinje cell synapses.
Cerebellum 12,657-666

Tanaka S, Kawaguchi S, Shioi G & Hirano T. (2013)
Long-term potentiation of inhibitory synaptic transmission onto cerebellar Purkinje neurons contributes to adaptaion of vestibulo-ocular reflex.
J.Neurosci 33,17209-17220.

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2012

2012

Tanaka H, and Hirano T (2012)
Visualization of subunit-specific delivery of glutamate receptors to postsynaptic membrane during hippocampal long-term potentiation.
Cell Reports 1, 291-298

Ryu K, Yokoyama M, Yamashita M, Hirano T. (2012)
Induction of excitatory and inhibitory presynaptic differentiation by GluD1.
Biochem Biophys Res Commun.417,157-161.

Hayashi Y, Tagawa Y, Yawata S, Nakanishi S, Funabiki K. (2012)
Spatio-temporal control of neural activity in vivo using fluorescence microendoscopy.
European Journal of Neuroscience, 2012, 36(6):2722-32.

Hirano T. (2012)
Glutamate-receptor-like molecule GluRδ2 involved in synapse formation at parallel fiber-Purkinje neuron synapses.
The Cerebellum 11:71-77.

Tagawa Y & Hirano T. (2012)
Activity-dependent callosal axon projections in neonatal mouse cerebral cortex.
Neural Plasticity, 2012:797295.

Hirano T. & Kawaguchi S. (2012)
Regulation of inhibitory synaptic plasticity in a Purkinje neuron.
The Cerebellum 11: 453-454.

Hirano T. (2012)
GABA and synaptic transmission in the cerebellum.
In "Handbook of the Cerebellum and Cerebellar Disorders" Springer (eds) (On line)

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2011

2011

Kawaguchi SY, Nagasaki N, and Hirano T (2011)
Dynamic impact of temporal context of Ca2+ signals on inhibitory synaptic plasticity.
Scientific Reports 1,143,1-12.

Hirano T, Kawaguchi SY. (2011)
Regulation of Inhibitory Synaptic Plasticity in a Purkinje Neuron.
Cerebellum.(E pub）

Miyawaki H, Hirano T.(2011)
Different correlations among physiological and morphological properties at single glutamatergic synapses in the rat hippocampus and the cerebellum.
Synapse. 65, 412-423.

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2010

2010

Mizuno H, Hirano T, and Tagawa Y. (2010)
Pre-synaptic and post-synaptic neuronal activity supports the axon development of callosal projection neurons during different post-natal periods in the cerebral cortex.
Eur. J. Neurosci. 31, 410-424.

Kuroyanagi T, Hirano T. (2010)
Flap loop of GluD2 binds to Cbln1 and induces presynaptic differentiation.
Biochem Biophys Res Commun. 398, 537-541.

Muguruma K, Nishiyama A, Ono Y, Miyawaki H, Mizuhara E, Hori S, Kakizuka A, Obata K, Yanagawa Y, Hirano T, Sasai Y. (2010)
Ontogeny-recapitulating generation and tissue integration of ES cell-derived Purkinje cells.
Nat Neurosci.13, 1171-1180.

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2009

2009

Ageta-Ishihara N, Takemoto-Kimura S, Nonaka M, Adachi-Morishima A, Suzuki K, Kamijo S, Fujii H, Mano T, Blaeser F, Chatila TA, Mizuno H, Hirano T, Tagawa Y, Okuno H, & Bito H. (2009)
Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade.
J. Neurosci. 29(43), 13720-13729.

Kitagawa, Y., Hirano, T. and Kawaguchi, S. (2009)
Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity.
Mol. Syst. Biol. 5, 280.

Kuroyanagi, T., Yokoyama, M. and Hirano, T (2009)
Postsynaptic glutamate receptor δ family contributes to presynaptic terminal differentiation and establishment of synaptic transmission.
Proc. Natl. Acad. Sci. USA 106, 4912-4916.

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2008

2008

Ohtsuki, G. and Hirano, T. (2008)
Bidirectional plasticity at developing climbing fiber - Prukinje neuron synapses.
Eur. J. Neurosci. 28, 2393-2400.

Takeuchi, T., Ohtsuki, G. Yoshida, T., Fukaya, M., Wainai, T., Yamashita, M., Yamazaki, Y., Mori, H., Sakimura, K., Kawamoto, S., Watanabe, M., Hirano, T. and Mishina, M. (2008)
Enhancement of Both Long-Term Depression Induction and Optokinetic Response Adaptation in Mice Lacking Delphilin.
Plos ONE 3,e2297,1-11.

Tsuruno, S., Kawaguchi, S. and Hirano, T. (2008)
Src-family protein tyrosine kinase negatively regulates cerebellar long-term depression.
Neurosci. Res. 61:329-332.

Sugiyama, Y., Kawaguchi, S. and Hirano, T. (2008)
mGluR1-mediated facilitation of long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron.
Eur. J. Neurosci. 27, 884-896.

Tagawa, Y., Mizuno, H. and Hirano T. (2008)
Activity-dependent development of interhemispheric connections in the visual cortex.
Reviews in the Neurosciences 19:19-28.

Kawaguchi, S. and Hiranno, T. (2008)
Regulatory mechanism of plasticity at GABAA receptor-mediated synapse.
In "Amino Acid Receptor Research." Nova Science Publishers, Inc. (In press)

Tsuruno, S. and Hirano, T. (2008)
Synaptic plasticity and motor learning in the cerebellum.
In "Synaptic Plasticity: New Research" Nova Science Publishers, Inc. (In press)

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2007

2007

Wada, N., Kishimoto, Y. Watanabe, D., Kano, M., Hirano, T., Funabiki, K. and Nakanishi, S. (2007)
Conditioned eyeblink learning is formed and stored without cerebellar granule cell transmission.
Proc. Natl. Acad. Sci. USA 104: 16690-16695.

Umeshima, H., Hirano, T. and Kengaku, M. (2007)
Microtube-based nuclear movement occurs independently of centrosome positioning in migrating neurons.
Proc. Natl. Acad. Sci. USA 104: 16182-16187.

Shima, Y., Kawaguchi, S. Kosaka, K., Nakayama, M., Hoshino, M., Nabeshima, Y., Hirano, T. and Uemura, T. (2007)
Opposing roles in neurite growth control by two 7-pass transmembrane cadherins.
Nat. Neurosci. 10: 963-969.

Kawaguchi, S. and Hirano, T. (2007)
Sustained GABARAP structural change underlies long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron.
J. Neurosci. 27: 6788-6799.

Mizuno, H., Hirano, T. and Tagawa, Y. (2007)
Evidence for activity-dependent cortical wiring: formation of interhemispheric connections in neonatal mouse visual cortex requires projection neuron activity.
J. Neurosci. 27: 6760-6770.

Tsuruno, S. and Hirano, T. (2007)
Persistent activation of protein kinase Cα is not necessary for expression of cerebellar long-term depression.
Mol. Cell. Neurosci. 35: 38-48.

Fujishima, K., Kurisu, J., Hirano, T. and Kengaku, M. (2007)
Targeted disruption of Sept3, a binding partner of Sept5 and Sept7, unaffects neuronal development in the central nervous system.
J. Neurochem. 102: 77-92.

Yoshida, T., Funabiki, K. and Hirano, T. (2007)
Increased occurrence of climbing fiber inputs to the cerebellar flocculus in a mutant mouse is correlated with the timing delay of optokinetic response.
Eur. J. Neurosci. 25: 1467-1474.

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2006

2006

Yawata, S., Tsuchida, H., Kengaku, M. and Hirano, T. (2006)
Membrane-proximal region of GluRδ2 is critical for LTD and interaction with PICK1 in a cerebellar Purkinje neuron.
J. Neurosci. 26: 3626-3633.

Kawaguchi, S. and Hirano, T. (2006)
Integrin α3β1 Suppresses Long-term Potentiation at Inhibitory Synapses on the Cerebellar Purkinje Neuron.
Mol. Cell. Neurosci. 31: 416-426.

Hirano, T. (2006)
Cerebellar regulation mechanisms learned from studies on GluRδ2, a unique glutamate-receptor-related molecule specifically expressed at parallel fiber-Purkinje cell synapses.
Mol. Neurobiol. 33: 1-16.

Tohgo, A., Eiraku, M., Miyazaki, T., Miura, E., Kawaguchi, S., Nishi, M., Watanabe, M., Hirano, T., Kengaku, M. and Takeshima, H. (2006)
Impaired cerebellar functions in mutant mice lacking DNER.
Mol. Cell. Neurosci. 31: 326-333.

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2005

2005

Eiraku, M., Tohgo, A., Ono, K., Kaneko, M., Fujishima, K., Hirano, T. and Kengaku, M. (2005)
DNER acts as a neuron-specific Notch ligand during Bergman glial development.
Nature Neurosci. 8: 873-880.

Tagawa, Y., Kanold, PO., Majdan, M. and Shatz, CJ. (2005)
Multiple Periods of Functional Ocular Dominance Plasticity in Mouse Visual Cortex.
Nature Neurosci. 8: 380-388.

Katoh, A., Yoshida, T., Himeshima, Y., Mishina, M. and Hirano, T. (2005)
Defective control and adaptation of reflex eye movements in mutant mice deficient in either the glutamate receptor δ2 subunit or Purkinje cells.
Eur. J. Neurosci. 21: 1315-1326.

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2004

2004

Ohtsuki, G., Kawaguchi, S., Mishina, M. and Hirano, T. (2004)
Enhanced inhibitory synaptic transmission in the cerebellar molecular layer of the GluRδ2 knockout mouse.
J. Neurosci. 24: 10900-10907.

Shima, Y., Kengaku, M., Hirano, T., Takeichi, M. and Uemura, T. (2004)
Regulation of dendritic maintenance and growth by a mammalian 7-pass transmembrane cadherin.
Dev. Cell 7: 205-216.

Yoshida, T., Katoh, A., Ohtsuki, G., Mishina, M. and Hirano, T. (2004)
Oscillating Purkinje Neuron Activity Causing Involuntary Eye Movement in a Mutant Mouse Deficient in the Glutamate Receptor δ2 Subunit.
J. Neurosci. 24: 2440-2448.

Kawaji, K., Umeshima, H., Eiraku, M., Hirano T. and Kengaku, M. (2004)
Dual phases of migration of cerebellar granule cells guided by axonal and dendritic leading processes.
Mol. Cell. Neurosci. 25: 228-240.

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2003

2003

Minami, I., Kengaku, M., Smitt, PS., Shigemoto, R. and Hirano, T. (2003)
Long-term potentiation of mGluR1 activity by depolarization-induced Homer1a in mouse cerebellar Purkinje neurons.
Eur J Neurosci. 17(5):1023-32.

Kitano, J., Nishida, M., Itsukaichi, Y., Minami, I., Ogawa, M., Hirano, T., Mori, Y. and Nakanishi, S. (2003)
Direct interaction and functional coupling between metabotropic glutamate receptor subtype 1 and voltage-sensitive CaV2.1 Ca2+ channel.
J. Biol. Chem. 278: 25101-25108.

Coesmans, M., Sillevis Smitt, P. A., Linden, D. J., Shigemoto, R., Hirano, T., Yamakawa, Y., Van Alphen, A. M., Luo, C., Van Der Geest, J. N., Kros, J., M., Gaillard, C. A., Frens, M. A. and De Zeeuw, C. I. (2003)
Mechanism underlying cerebellar motor deficits due to mGluR1-autoantibodies.
Ann. Neurol. 53: 325-336.

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2002

2002

Kawaguchi, S. and Hirano, T. (2002)
Signaling cascade regulating long-term potentiation of GABAA Receptor Responsiveness in Cerebellar Purkinje Neurons.
J.Neurosci. 22(10): 3969-3976 .

Fujii, H. and Hirano, T. (2002)
Calcineurin regulates induction of late phase of cerebellar long-term depression in rat cultured Purkinje neurons.
Eur J Neurosci. 16(9): 1777-88.

Eiraku, M., Hirata, Y., Takeshima, H., Hirano, T. and Kengaku, M. (2002)
Delta/Notch-like EGF-related Receptor (DNER), a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons.
J. Biol. Chem. 277(28): 25400-25407.

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2001

2001

Yamasaki, T., Kawaji, K., Ono, K., Bito, H., Hirano, T., Osumi, N., and Kengaku, M. (2001)
Pax6 regulates granule cell polarization during parallel fiber formation in the developing cerebellum.
Development 128: 3133-3144

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2000

2000

Kawaguchi, SY. and Hirano, T. (2000)
Suppression of Inhibitory Synaptic Potentiation by Presynaptic Activity through postsynaptic GABAB Receptors in a Purkinje Neuron.
Neuron 27: 339-347 .

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1999

1999

Murashima, M. and Hirano, T. (1999)
Entire course and distinct phases of day-lasting depression of mEPSC amplitudes in coultured Purkinje neurons.
J. Neurosci. 19: 7317-7325

Kawasaki, H., Fujii, H., Gotho, Y., Morooka, T., Shimohama, S., Nishida, E. and Hirano, T. (1999)
Requirement for mitogen-activated protein kinase in cerebellar long-term depression.
J. Biol. Chem. 274: 13498-14502

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1998

1998

Watanabe, D., Inokawa, H., Hashimoto, K., Suzuki, N., Kano, M., Shigemoto, R., Hirano, T., Toyama, K., Kaneko, S., Yokoi, M., Mriyoshi, K., Suzuki,M., Kobayashi, K., Nagatsu, T., Kreitman, R. J., Pastan, I. And Nakanishi, S. (1998)
Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor avtivation in motor coordination.
Cell 95: 17-28.

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Before 1997

Before 1997

Kadotani, H., Hirano, T., Masugi, M., Nakamura, K., Nakao, K., Katsuki, M. and Nakanishi, S. (1996)
Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but noto from single disruption of the NR2A or NR2C subunit.
J. Neurosci. 16: 7859-7867.

Kashiwabuchi, N., Ikeda, K., Araki, H., Hirano, T., Shibuki, K., Takayama, C., Inoue, Y., Katsuwada, T., Yagi, T., Kang, Y., Aizawa, S. and Mishina, M. (1995)
Disturbed motor coordination, Purinje cell synapse formation and cerebellar disrupted long-term depression of mice defective in the δ2 subunit of the glutamate receptor channel.
Cell. 81:245-252.

Hirano, T., Kasono, K., Araki, K., Shinozuka, K. and Mishina, M. (1994)
Involvement of the glutamate receptor δ2 subunit in the long-term depression of glutamate responsiveness in cultured rat Purkinje cells.
Neursci. Lett. 182: 172-176.

Shigemoto, R., Abe, T., Nomura, S., Nakanishi, S. and Hirano, T. (1994)
Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells.
Neuron 12: 1245-1255.

Hirano, T. and Kasono, K. (1993)
Spatial distribution of excitatory and inhibitory synapses on a Purkinje cell in a rat cerebellar culture.
J. Neurophysiol. 70: 1316-1325.

Hirano, T. (1991)
Differential pre- and postsynaptic mechanisms for synaptic potentiation and depression between a granule cell and a Purkinje cell in rat cerebellar culture.
Synapse 7:321-323.

Hirano, T. (1990)
Depression and potentiation of the synaptic transmission between a granule cell and a Purkinje cell in rat cerebellar culture.
Neursci. Lett. 119: 141-144.

Hirano, T. (1990)
Effects of postsynaptic depolarization in the induction of synaptic depression between a granule cell and a Purkinje cell in rat cerebellar culture.
Neursci. Lett. 119: 145-147.

Hirano, T. (1990)
Synaptic transmission between rat inferior olivary neurons and cerebellar Purkinje cells in culture.
J. Neurophysiol. 63: 181-189.

Hirano, T. and Hagiwara, S. (1988)
Synaptic transmission between rat cerebellar granule and Purkinje cells in dissociated cell culture: effects of excitatory-amino acid transmitter antagonists.
Proc. Natl. Acad. Sci. USA 85: 934-938.

Hirano, T. and Ohmori, H. (1986)
Voltage-gated and synaptic currents in rat Purkinje cells in dissociated cell cultures.
Proc. Natl. Acad. Sci. USA 83: 1945-1949.

Hirano, T., Kubo, Y. and Wu, M.M. (1986)
Cerebellar granule cells in culture: monosynaptic connections with Purkinje cells and ionic currents.
Proc. Natl. Acad. Sci. USA 83: 4957-4961.